Johns Hopkins University · PhysiologyCell Dynamics Lab
Jie Xiao · Baltimore, Maryland
Research Focus
The research lab led by Jie Xiao at Johns Hopkins University focuses on understanding how bacteria manage essential processes like cell wall construction and chromosome organization. Using E. coli as a model organism, the team aims to uncover the molecular details that regulate these processes in living cells. They leverage advanced techniques such as single-molecule imaging and computational modeling to study the dynamics and interactions of proteins involved in these crucial cellular activities.
bacterial cell wallchromosome organizationE. colisingle-molecule imagingbiochemical analysis
Research Aims
5AIM 01Investigate the molecular mechanisms of cell wall constriction in bacteria.
AIM 02Elucidate the dynamics of chromosome organization in E. coli.
AIM 03Identify the protein interactions involved in bacterial cell division.
AIM 04Understand the regulatory roles of small noncoding RNAs in genome compaction.
AIM 05Explore the balance between cell wall synthesis and degradation during division.
Skills the Lab Values
single-molecule imagingcell culturebiochemical assaysmutational analysiscomputational modeling
Output against the department
Publications556top 5% of dept.13th of 286
this lab
most publishedleast published
Citations52ktop 3% of dept.8th of 286
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.