University of Kentucky · PhysiologyThe ChronoCardia Lab
Brian P Delisle · Lexington, Kentucky
Research Focus
Dr. Brian P. Delisle's lab at the University of Kentucky focuses on understanding how circadian rhythms influence heart function and arrhythmias. They study the molecular mechanisms that control the timing of essential genes and proteins in the heart and how changes in daily eating patterns can affect heart health. The findings aim to develop strategies to reduce the risk of heart-related issues in vulnerable populations by aligning their biological clocks with their eating habits.
circadian rhythmscardiac arrhythmiasion channel regulationgene expressionautonomic nervous system
Research Aims
3AIM 01Elucidate molecular mechanisms of circadian regulation of cardiac ion channel genes.
AIM 02Determine effects of circadian alignment on transcription and translation of cardiac genes.
AIM 03Assess physiological implications of circadian rhythms on cardiac function and arrhythmia susceptibility.
Skills the Lab Values
mRNA sequencingRibo-seqbioluminescence assaysChromatin Immunoprecipitation (ChIP)electrophysiologymouse modelstranscriptional regulationtranslational regulationbioinformatics
Output against the department
Publications157top 47% of dept.133rd of 286
this lab
most publishedleast published
Citations4.4kbottom 36% of dept.182nd of 286
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.