RURush University · Neuroscience
Buchman Resilience Lab
Aron S Buchman · Chicago, Illinois
Research Focus
Dr. Aron S Buchman's lab at Rush University Medical Center focuses on understanding how some older adults maintain their movement abilities and cognitive functions despite having Alzheimer's disease and related dementias (ADRD). They are investigating specific proteins and genetic factors that contribute to this resilience, aiming to discover potential targets for future treatments. By measuring and analyzing movement and cognitive metrics, the lab seeks to improve early prediction of Alzheimer's dementia and explore the biological mechanisms behind motor and cognitive functions.
Alzheimer's diseasemotor resiliencecognitive resilienceproteomicsdigital phenotypingelderly mobilitybiomarkerssystems biologyrisk factors
Research Aims
4AIM 01Identify resilience proteins in motor tissues related to Alzheimer's disease and cognitive decline.
AIM 02Use digital phenotyping to improve prediction of Alzheimer's dementia through mobility metrics.
AIM 03Evaluate the relationship between motor resilience and cognitive resilience proteins.
AIM 04Explore how resilience proteins connect risk factors with motor and cognitive decline.
Skills the Lab Values
RNA sequencingproteomicsmotor function assessmentcognitive testingdata analysisstatistical softwarebioinformaticsdeep omics methodsdigital mobility tracking
Output against the department
Publications446top 14% of dept.91st of 671
this lab
most publishedleast published
Citations28ktop 14% of dept.96th of 671
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.