University of Michigan-Ann Arbor · PharmacologyCancer Immunotherapy and Vaccine Development Unit
Duxin Sun · Ann Arbor, Michigan
Research Focus
Duxin Sun's lab at the University of Michigan focuses on innovative cancer therapies, specifically a new type of cancer vaccine known as VAM-B/CD4. This vaccine is designed to enhance the interactions between B cells and CD4 T cells, which is essential for generating a long-lasting immune response against various types of cancers. The lab aims to improve the efficacy of cancer immunotherapy by incorporating B cell-targeted strategies into vaccine design, potentially leading to better outcomes for patients.
cancer vaccineT cell immunityB cell activationimmunotherapyneoantigensnanotechnologyantigen presentationclinical researchcancer therapeutics
Research Aims
5AIM 01Develop a novel cancer vaccine that promotes B/CD4 T cell crosstalk.
AIM 02Enhance B cell-mediated antigen presentation for improved immune response.
AIM 03Investigate the role of viral epitopes in cancer vaccine efficacy.
AIM 04Optimize delivery systems for B cell epitope binding.
AIM 05Evaluate the long-term efficacy of B/CD4 T cell interactions in diverse cancer models.
Skills the Lab Values
vaccine designflow cytometrycell cultureanimal modelsantigen presentation assaysB cell immunology techniquesdendritic cell studiesdata analysis using Pythonimmune response assays
Output against the department
Publications458top 12% of dept.55th of 462
this lab
most publishedleast published
Citations22ktop 15% of dept.70th of 462
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.