University of Chicago · BiologyThe Autoimmunity Nexus
Alexander V Chervonsky · Chicago, Illinois
Research Focus
Dr. Alexander V. Chervonsky's lab focuses on understanding how sex differences and diet impact autoimmune diseases, particularly Type 1 diabetes (T1D). They study the role of hormones and gut microbes in disease mechanisms and are exploring dietary interventions that may help prevent or treat these conditions. By combining experimental models and advanced computational methods, the lab aims to identify new approaches to manage autoimmune diseases that disproportionately affect women.
autoimmunityType 1 diabetessex differencesdietary interventionsgut microbiota
Research Aims
4AIM 01Investigate how sex hormones influence T cell function in autoimmune disease.
AIM 02Study the impact of gut microbiota on the development of Type 1 diabetes.
AIM 03Analyze how dietary gluten affects immune response in relation to microbiota.
AIM 04Explore the role of immune cells in the progression of autoimmunity.
Skills the Lab Values
mouse modelssingle cell sequencingmultiparameter flow cytometrygene expression analysiscell cultureprotein assaysbioinformaticsimmunohistochemistryT cell functional assays
Output against the department
Publications107bottom 37% of dept.648th of 1,033
this lab
most publishedleast published
Citations9.8ktop 38% of dept.396th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.