Columbia University in the City of New York · BiologyDalla-Favera Lymphoma Lab
Riccardo Dalla-Favera · New York, New York
Research Focus
Dr. Riccardo Dalla-Favera's lab focuses on understanding diffuse large B cell lymphoma (DLBCL), a common and challenging type of blood cancer. The research team is uncovering genetic mutations within the non-coding regions of DNA that play a critical role in DLBCL. By analyzing super-enhancers—regulatory regions of the genome—they aim to identify new therapeutic targets and improve treatment options for patients who currently have limited options.
Diffuse Large B Cell LymphomaB-LymphocytesGenomic AlterationsSuper-EnhancersCRISPROncogenesCancer TherapeuticsGenome SequencingNon-Coding GenomeLymphomagenesis
Research Aims
5AIM 01Identify recurrent mutations in super-enhancers in DLBCL.
AIM 02Dissect the functional impact of super-enhancer mutations on gene regulation.
AIM 03Investigate the role of the glucocorticoid receptor in lymphomagenesis.
AIM 04Explore connections between super-enhancers and known oncogenes.
AIM 05Aim to improve therapeutic strategies targeting genetic alterations in DLBCL.
Skills the Lab Values
CRISPR/Cas9Genome SequencingCell CultureFlow CytometryMolecular CloningRNA ExtractionWestern BlottingCell Line DevelopmentGenetic ProfilingData Analysis
Output against the department
Publications430top 10% of dept.105th of 1,033
this lab
most publishedleast published
Citations56ktop 4% of dept.40th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.