MCWMedical College of Wisconsin · Physiology
The Angiotensin Nexus
Justin L Grobe · Milwaukee, Wisconsin
Research Focus
Dr. Justin Grobe's lab explores how specific neurons in the brain regulate blood pressure and metabolism, particularly how these functions change when someone becomes obese. The research focuses on the role of angiotensin receptors in neurons that respond to hunger signals and how their signaling pathways are altered during obesity. By understanding these changes, the lab aims to find new insights that could help manage obesity and hypertension in the population.
angiotensin receptorscardiometabolic controlobesityhypothalamic neuronsblood pressure
Research Aims
2AIM 01Define the normal signaling cascade of AT1A receptors in AgRP neurons in lean animals.
AIM 02Investigate how G protein signal switching in these neurons contributes to RMR adaptation during obesity.
Skills the Lab Values
advanced electrophysiologytransgenic animal modelsviral delivery methodscardiometabolic phenotypingchemogenetic techniques
Output against the department
Publications393top 9% of dept.27th of 286
this lab
most publishedleast published
Citations5.9kbottom 47% of dept.152nd of 286
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.