University of Chicago · BiochemistryThe Myosin Movement Lab
Ronald S Rock · Chicago, Illinois
Research Focus
Dr. Ronald S. Rock's lab studies how specific motor proteins called myosins move and function within cells. They focus on myosin-10, which plays a crucial role in delivering important molecules to areas of the cell that help it move, especially during cell division and in cancer metastasis. By understanding how these proteins are regulated and how they navigate within cells, the lab aims to shed light on fundamental biological processes and improve our understanding of cell movement in health and disease.
myosin-10cell motilitymotor proteinscancer metastasisstructural biologycell divisionfilopodiacytoskeletal regulationmolecular motors
Research Aims
4AIM 01Investigate how myosin-10 navigates to specific locations within the cell.
AIM 02Explore the regulatory mechanisms that control myosin-10 motility.
AIM 03Analyze the effects of ligand binding on myosin-10 function and structure.
AIM 04Determine how myosin-10 contributes to cell movement in both normal and cancerous cells.
Skills the Lab Values
structural biologycryoelectron microscopymolecular modelingin vitro assaysprotein purificationligand binding assayscell culturebiophysical techniquesmicroscopy
Output against the department
Publications108bottom 27% of dept.291st of 402
this lab
most publishedleast published
Citations4.1kbottom 22% of dept.312th of 402
this lab
most citedleast cited
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