George Washington University · BiochemistryZhu Lab
Wenge Zhu · Washington, District of Columbia
Research Focus
Dr. Wenge Zhu's research lab at George Washington University focuses on understanding and overcoming resistance to breast cancer therapies. The lab investigates how specific molecular pathways influence both CDK4/6 inhibitor and aromatase inhibitor resistance, aiming to develop novel therapeutic strategies for patients with advanced breast cancer. By studying the roles of specific proteins and gene mutations, Dr. Zhu's team seeks to improve treatment outcomes for affected patients.
breast cancerdrug resistanceCDK4/6 inhibitorsaromatase inhibitorsmolecular mechanismsR-loopcell signalingtherapeutic strategiesO-GlcNAcylation
Research Aims
5AIM 01Investigate the molecular mechanism regulating CDK4/6 inhibitor resistance in breast cancer cells.
AIM 02Evaluate new drug combinations for treating CDK4/6 inhibitor resistance in patient models.
AIM 03Determine the role of And-1 in R-loop resolution and endocrine resistance in breast cancer.
AIM 04Assess the effects of And-1 inhibitors on aromatase inhibitor resistance in preclinical models.
AIM 05Conduct clinical studies to relate findings to patient outcomes.
Skills the Lab Values
cell culturemouse modelshigh-throughput screeningin vivo assaysdrug combination testingmolecular cloningWestern blotting RNA sequencinggene expression analysis
Output against the department
Publications65bottom 11% of dept.354th of 402
this lab
most publishedleast published
Citations2.4kbottom 10% of dept.362nd of 402
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.