Harvard University · BiologyHair Follicle Stem Cell Aging Lab
Ya-Chieh Hsu · Cambridge, Massachusetts
Research Focus
Dr. Ya-Chieh Hsu's research lab at Harvard University focuses on understanding how stem cells age, particularly hair follicle stem cells (HFSCs). The lab studies the loss of regenerative capacity in aging stem cells and seeks to identify genes that could rejuvenate these cells. By employing advanced genetic techniques and innovative methods, the team aims to uncover the cellular changes that occur as HFSCs age, with hopes of developing therapies to combat age-related declines in stem cell function.
stem cell aginghair follicle stem cellsregenerative medicinegenetic manipulationrejuvenationmolecular mechanismsAAV vectorsage-related declinecellular signaling
Research Aims
5AIM 01Identify genes that drive age-related dormancy in hair follicle stem cells.
AIM 02Investigate the cellular and molecular mechanisms that lead to stem cell rejuvenation.
AIM 03Utilize adeno-associated viral vectors for targeted gene manipulation in aged mice.
AIM 04Assess chromatin and transcriptomic changes in aging stem cells.
AIM 05Develop therapeutic strategies to counteract age-related decline in stem cell functions.
Skills the Lab Values
gene editing with AAV vectorsRNA sequencingin vivo genetic manipulationimmunofluorescencecell culture techniquesmouse modelschromatin analysistranscriptome studiesdata analysis using Python
Output against the department
Publications55bottom 13% of dept.892nd of 1,033
this lab
most publishedleast published
Citations6.3kbottom 45% of dept.564th of 1,033
this lab
most citedleast cited
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