Stanford University · BiochemistryBrandman Proteostasis Lab
Onn Brandman · Stanford, California
Research Focus
The research lab, led by Dr. Onn Brandman at Stanford University, investigates how cells respond to stress and maintain the stability of proteins, essential for healthy cell function. By studying the mechanisms of protein production and quality control, the lab seeks to uncover insights into how these processes go awry in diseases and during aging. Their work aims to advance our understanding of cellular survival strategies and the fundamental biology behind diseases.
stress response pathwaysprotein homeostasisribosome-associated quality controlbiophysical responsescell survivaldisease mechanismsmolecular biologyagingproteostasisviscoadaptation
Research Aims
5AIM 01Investigate how cells detect and respond to defective protein translation.
AIM 02Explore the mechanisms of ribosome-associated quality control.
AIM 03Study the biophysical responses of cells to stress conditions.
AIM 04Analyze the role of CArboxyl-terminal Tails in protein synthesis.
AIM 05Understand how stress response pathways contribute to cellular health and disease.
Skills the Lab Values
protein purificationbiophysical analysiscell culturemolecular cloningRNA sequencingWestern blottingmicroscopydata analysis with Pythonexperimental designquality control assays
Output against the department
Publications79bottom 16% of dept.335th of 402
this lab
most publishedleast published
Citations8.4kbottom 45% of dept.222nd of 402
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.