Columbia University in the City of New York · Microbiology & ImmunologyChung RNA Lab
Hachung Chung · New York, New York
Research Focus
Dr. Hachung Chung's research lab at Columbia University focuses on understanding how specific RNA structures contribute to immune responses and inflammation, particularly in neurons. They investigate the role of long 3' untranslated regions (3'UTRs) in generating immunostimulatory double-stranded RNA (dsRNA), which can trigger autoinflammatory diseases when dysregulated. The lab's work aims to uncover the mechanisms behind RNA lengthening and dsRNA production, with the potential for developing new therapies for neuroinflammatory conditions.
RNA structureimmunostimulatory RNAneuroinflammationdouble-stranded RNA3'UTRpattern recognition receptorsAicardi-Goutières syndromegenome engineeringdsRNA sequencingtherapeutic strategies
Research Aims
3AIM 01Identify additional genes that extend 3'UTRs and increase dsRNA production.
AIM 02Determine the mechanism by which Hu proteins lengthen 3'UTRs and elevate dsRNA levels.
AIM 03Investigate the impact of 3'UTRs in a model of Aicardi-Goutières syndrome.
Skills the Lab Values
genome engineeringPCRRNA sequencingdsRNA imagingcell culturebiochemistry techniquesflow cytometrybioinformaticsmicroscopycell differentiation
Output against the department
Publications19bottom 3% of dept.468th of 486
this lab
most publishedleast published
Citations2.9kbottom 20% of dept.391st of 486
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.