Puglisi Lab

Joseph D Puglisi's lab at Stanford University focuses on understanding how protein translation works, especially in relation to neurodegenerative diseases like Alzheimer's and ALS. They look into an unusual form of translation called RAN translation, which can lead to the production of harmful proteins when certain genetic sequences are repeated too many times. By combining techniques from biophysics and genetics, the lab aims to uncover how translation mechanisms can go awry and what can be done to mitigate their effects on health.