Columbia University in the City of New York · PhysiologyThe Hematopoietic Frontier
Stavroula Kousteni · New York, New York
Research Focus
Dr. Stavroula Kousteni's lab at Columbia University Health Sciences focuses on understanding the molecular and epigenetic changes in hematopoietic stem cells (HSCs) that contribute to diseases like myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML) as patients age. They investigate how factors such as mutations, inflammation, and changes in the bone marrow microenvironment influence the evolution of these blood disorders. The lab aims to uncover potential therapeutic targets for improving treatments or preventing the progression of these conditions.
Myelodysplastic syndromesacute myeloid leukemiaaginghematopoietic stem cellsepigeneticsbone marrow microenvironmentclonal hematopoiesisNucleoporinsIDH mutationsdysmyelopoiesis
Research Aims
5AIM 01Investigate the role of Nucleoporins in MDS development from aging-related factors.
AIM 02Examine how mutations in IDH1/2 affect epigenetic changes in osteoblasts and their impact on HSCs.
AIM 03Identify the mechanisms through which the aging bone marrow microenvironment influences leukemia progression.
AIM 04Determine potential therapeutic targets for IDH mutant MDS/AML.
AIM 05Utilize single cell technology to study clonal evolution in hematological malignancies.
Skills the Lab Values
mouse modelshuman iPSC modelsflow cytometryRNA sequencinggenetic manipulationcell culturemethylation analysisprotein assaystranscriptional profilingbioinformatics
Output against the department
Publications124bottom 38% of dept.176th of 286
this lab
most publishedleast published
Citations9.5ktop 36% of dept.102nd of 286
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.