University of Kentucky · Microbiology & ImmunologyThe Regenerative Macrophage Lab
Jennifer Simkin · Lexington, Kentucky
Research Focus
Dr. Jennifer Simkin's lab at the University of Kentucky focuses on understanding how macrophages, a type of immune cell, can promote regeneration in bone and soft tissue following injuries, such as amputations. By studying different types of macrophages in a mouse model, the lab aims to uncover the mechanisms that allow these cells to aid healing and potentially develop new therapies for humans.
macrophagesbone regenerationtissue healingscar formationregenerative medicine
Research Aims
3AIM 01Investigate the unique metabolic profile of macrophages involved in tissue regeneration.
AIM 02Evaluate how macrophages can create a regenerative environment during fibrotic healing.
AIM 03Identify molecular signals that macrophages use to influence neighboring cells for regeneration.
Skills the Lab Values
cell culturemouse modelssingle cell RNA sequencingspatial transcriptomicsmetabolic manipulation
Output against the department
Publications45bottom 8% of dept.444th of 486
this lab
most publishedleast published
Citations1.5kbottom 9% of dept.442nd of 486
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.