University of Florida · BiochemistryGlycogen Metabolism and Neurological Disease Lab
Matthew S. Gentry · Gainesville, Florida
Research Focus
Dr. Matthew S. Gentry's lab at the University of Florida focuses on how brain metabolism and glycogen storage are linked to neurological diseases, particularly Lafora disease and Alzheimer's disease. They study how abnormal aggregates of glycogen, known as polyglucosan bodies, contribute to disease progression and seek to develop potential therapies to address these conditions. The research aims to understand the cellular mechanisms behind these diseases and to explore therapeutic options to restore healthy brain function.
glycogen metabolismneurological diseaseLafora diseaseAlzheimer's diseasepolyglucosan bodiesbrain metabolismglycogen storage diseasecellular physiologytherapeutic developmentbiomarker development
Research Aims
5AIM 01Investigate the role of polyglucosan bodies in Lafora disease and other neurological diseases.
AIM 02Determine the molecular mechanisms by which glycogen metabolism is altered in these conditions.
AIM 03Develop novel therapeutic strategies to address brain metabolic perturbations.
AIM 04Establish biomarkers for monitoring disease progression and therapeutic efficacy.
AIM 05Translate laboratory findings into pre-clinical therapeutic approaches.
Skills the Lab Values
cell culturemouse modelsbiochemical assaysWestern blotPCRimmunohistochemistryRNA extractionmetabolic analysisdata interpretationtherapeutic testing
Output against the department
Publications226top 35% of dept.136th of 402
this lab
most publishedleast published
Citations5.1kbottom 29% of dept.284th of 402
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.