Yale University · BiochemistryThe LncRNA Dynamics Lab
Nadya M Dimitrova · New Haven, Connecticut
Research Focus
Dr. Nadya Dimitrova's lab at Yale University studies the role of long noncoding RNAs (lncRNAs), particularly Malat1, in lung adenocarcinoma (LUAD). They focus on how Malat1 contributes to cancer progression and the tumor microenvironment, using advanced mouse models and molecular biology techniques. The lab aims to uncover potential therapeutic targets by understanding how the deregulation of lncRNAs affects cancer development.
long noncoding RNAslung adenocarcinomacancer progressionCRISPRtumor microenvironmentmalat1therapeutic targetsmolecular biology
Research Aims
3AIM 01Investigate how Malat1 overexpression influences tumor initiation and progression in lung adenocarcinoma.
AIM 02Characterize the non-cell autonomous effects of Malat1 on the tumor microenvironment at various tumor stages.
AIM 03Elucidate the molecular mechanisms by which overexpressed Malat1 alters gene expression in tumor-associated cells.
Skills the Lab Values
CRISPR gene editingmouse modelscell culturemolecular cloningRNA sequencingWestern blottingbioinformaticscytokine analysisgene expression analysis
Output against the department
Publications35bottom 3% of dept.389th of 402
this lab
most publishedleast published
Citations2.6kbottom 11% of dept.356th of 402
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.