Boston University · BiologyShadow Enhancer Research Group
Zeba B Wunderlich · Boston, Massachusetts
Research Focus
Dr. Zeba B. Wunderlich's lab at Boston University studies how certain regulatory elements in DNA, called shadow enhancers, help ensure consistent gene expression during development. By exploring how these enhancers function and evolve, the lab hopes to uncover insights into developmental disorders such as autism and diabetes that arise from genetic and environmental factors. This research aims to connect the organization of these enhancers to their role in robust developmental processes.
shadow enhancersgene regulationdevelopmentautismgenetic mutationsenvironmental stressgene expressiondevelopmental biologytranscription factorsmodeling
Research Aims
3AIM 01Test hypotheses about shadow enhancer features that contribute to robust gene expression.
AIM 02Generate predictive models of enhancer function through systematic perturbations.
AIM 03Categorize the evolutionary origins and development of shadow enhancers.
Skills the Lab Values
PCRmRNA dynamics measurementin vitro perturbation assayssynthetic biology techniqueshigh throughput screeningdata modelingcomputer simulationstranscription factor analysisRNA sequencingmolecular cloning
Output against the department
Publications81bottom 24% of dept.779th of 1,033
this lab
most publishedleast published
Citations2.4kbottom 17% of dept.857th of 1,033
this lab
most citedleast cited
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