EUEmory University · Biology
ALS Genetics and Neurodegeneration Lab
Jie Jiang · Atlanta, Georgia
Research Focus
Dr. Jie Jiang's lab at Emory University studies the effects of genetic mutations linked to Amyotrophic Lateral Sclerosis (ALS), focusing specifically on the KIF5A gene. They investigate how a mutation in this gene leads to nerve cell degeneration. The lab uses various models to explore how altered protein functions and transport mechanisms contribute to the disease, aiming to discover new treatment avenues for ALS.
ALSKIF5Aneurodegenerationmotor neuronsRNA metabolism
Research Aims
3AIM 01Investigate the gain of function in transgenic mice expressing KIF5A mutations.
AIM 02Examine cargo transport deficits in induced pluripotent stem cell-derived motor neurons.
AIM 03Characterize the aggregation and toxicity of KIF5A-related protein aggregates.
Skills the Lab Values
transgenic micecell cultureproteomicsmicroscopyRNA sequencingmolecular cloningimmunohistochemistrybioinformaticsaffinity chromatography
Output against the department
Publications551top 6% of dept.65th of 1,033
this lab
most publishedleast published
Citations10ktop 36% of dept.374th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.