University of Michigan-Ann Arbor · PhysiologyThe Muscle Nexus Lab
Jun Hee Lee · Ann Arbor, Michigan
Research Focus
Jun Hee Lee's lab at the University of Michigan focuses on understanding the interplay between exercise, nutrition, and muscle health, particularly in the context of aging. They investigate how the protein Sestrins mediates the benefits of the amino acid leucine and exercise on maintaining muscle homeostasis, which is crucial for preserving mobility and overall health in older adults. Their research aims to clarify how these factors interact to inform better preventative strategies against muscle degeneration.
muscle healthagingleucineSestrinsexercisemetabolismmuscle homeostasismTORC1autophagynutritional interventions
Research Aims
5AIM 01Investigate the role of Sestrins in mediating muscle health benefits of exercise.
AIM 02Clarify the relationship between leucine intake and muscle homeostasis.
AIM 03Examine how Sestrins influence metabolic pathways involved in muscle aging.
AIM 04Develop methodologies for studying protein interactions in muscle tissue.
AIM 05Provide insights for therapeutic strategies to enhance muscle function in the elderly.
Skills the Lab Values
biochemical methodologiesgenetic manipulationmouse modelsprotein purification techniquestranscriptomic analysiscell cultureWestern blottingmetabolic pathway analysisdata analysisexperimental design
Output against the department
Publications188top 36% of dept.103rd of 286
this lab
most publishedleast published
Citations20ktop 14% of dept.39th of 286
this lab
most citedleast cited
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