UWMUniversity of Wisconsin-Madison · Biochemistry
Landick Lab
Robert Landick · Madison, Wisconsin
Research Focus
Dr. Robert Landick's research lab at the University of Wisconsin-Madison focuses on understanding how transcription processes are regulated in bacteria. By studying the interactions between RNA polymerase and regulatory molecules, the team seeks to uncover mechanisms that control gene expression through pausing and termination of transcription. This work has implications for antibiotics development and understanding gene regulation in human health.
transcription regulationRNA polymerasegene expressionantibioticsbacterial geneticschromatin structuremolecular biologysingle-molecule techniques
Research Aims
3AIM 01Integrate models of pausing and termination mechanisms across diverse bacterial lineages.
AIM 02Elucidate the molecular basis of pro- vs. anti-pausing and recruitment for NusGs and paralogs.
AIM 03Link genome-scale regulation in vivo to the molecular basis of elongation complex structural changes.
Skills the Lab Values
cryogenic electron microscopy (cryo-EM)RNA extraction and analysisgenome-scale techniquesstructural biochemistrymolecular cloningprotein purificationbacterial culturebiochemical assays
Output against the department
Publications337top 17% of dept.69th of 402
this lab
most publishedleast published
Citations23ktop 16% of dept.66th of 402
this lab
most citedleast cited
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