University of California-San Francisco · NeuroscienceGenetic Insights Lab
Yin Shen · San Francisco, California
Research Focus
Dr. Yin Shen's lab at UCSF focuses on understanding the genetic factors that contribute to Alzheimer's disease, specifically how risk genes and their variants influence gene expression and related biological functions. The lab uses advanced techniques such as CRISPR and single-cell analysis to study the interactions between these genetic factors and the disease. By examining nerve cells and brain organoids, the lab aims to uncover new insights that could lead to better risk predictions and therapeutic targets for Alzheimer's disease.
Alzheimer's DiseasegeneticsCRISPRgene expressioniPSC modelsfunctional assaysrisk predictionneurodegenerationcellular functions
Research Aims
5AIM 01Elucidate the roles of Alzheimer's disease risk genes in gene expression.
AIM 02Characterize enhancers associated with Alzheimer's risk genes.
AIM 03Determine the biological consequences of Alzheimer's risk variants using CRISPR and single-cell techniques.
AIM 04Investigate cellular functions related to Alzheimer's pathogenesis in various cell types.
AIM 05Identify causal variants that modulate gene expression and contribute to Alzheimer's disease.
Skills the Lab Values
CRISPRsingle-cell RNA sequencingcell cultureiPSC differentiationfunctional assaysgenome editingorganoid culturebiological benchmarkingdata analysis in genomics
Output against the department
Publications86bottom 26% of dept.493rd of 671
this lab
most publishedleast published
Citations6.9kbottom 47% of dept.353rd of 671
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.