University of Utah · NeuroscienceMigraine Mechanisms and Biomarkers Lab
Kevin Christopher Brennan · Salt Lake City, Utah
Research Focus
Dr. Kevin Christopher Brennan's lab focuses on understanding migraines, a debilitating condition that affects millions globally. The research investigates the mechanisms behind migraine attacks, particularly how sensory phenomena like auras may indicate the progression of migraines. By combining imaging techniques and physiological assessments, the lab aims to identify biomarkers that predict migraine severity and progression, ultimately helping to develop better treatments and preventative strategies.
migrainespreading depolarizationsensory amplificationneurologybiomarkersastrocytesneuronselectrophysiologycalcium signaling
Research Aims
3AIM 01Investigate the mechanisms underlying glutamate plume generation related to migraine auras.
AIM 02Examine the interaction between neurons and astrocytes in the context of migraine progression.
AIM 03Identify sensory amplifications as potential biomarkers for predicting migraine severity.
Skills the Lab Values
two-photon imagingwhole-cell recordingextracellular space measurementcalcium imagingelectrophysiological techniquesdata analysis softwareanimal modelsgenetic manipulationneuroscience techniques
Output against the department
Publications123bottom 43% of dept.379th of 671
this lab
most publishedleast published
Citations4.8kbottom 35% of dept.436th of 671
this lab
most citedleast cited
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