Indiana University-Purdue University-Indianapolis · PharmacologyCortical Excitability and Addiction Lab
Yao-Ying Ma · Indianapolis, Indiana
Research Focus
Dr. Yao-Ying Ma's lab at Indiana University Indianapolis focuses on understanding how certain brain cells contribute to cocaine addiction and relapse. By studying the excitability of specific neurons in the motor cortex, the lab aims to uncover mechanisms behind drug-seeking behavior, especially after withdrawal. The ultimate goal is to identify new targets for preventing relapse in individuals dealing with substance use disorders.
cocaine addictionrelapse mechanismscortical excitabilitymotor cortexdrug-seeking behaviorneurosciencesynaptic transmissionsubstance use disorder
Research Aims
3AIM 01Examine the excitability of cortical pyramidal neurons in the supplementary motor cortex.
AIM 02Investigate the excitatory transmission in the projections from the supplementary motor cortex to the dorsolateral striatum.
AIM 03Develop methods to prevent cocaine seeking behavior in rats with a history of cocaine use.
Skills the Lab Values
animal modelsintravenous self-administrationelectrophysiologypatch clampWestern blottingoptogeneticsneuron excitability assessmentbehavioral assaysneurotransmitter release measurement
Output against the department
Publications62bottom 11% of dept.408th of 462
this lab
most publishedleast published
Citations1.7kbottom 10% of dept.416th of 462
this lab
most citedleast cited
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