WFUWake Forest University · Biology
Debinski Immunotherapy Lab
Waldemar Debinski · Winston-Salem, North Carolina
Research Focus
Dr. Waldemar Debinski's lab focuses on innovative treatments for glioblastoma (GBM), a highly aggressive brain cancer. They are pioneering the use of drug conjugates that target specific receptors over-expressed in GBM cells, aiming to improve patient outcomes by combining direct tumor killing with immune system activation. The lab's research involves testing these therapies in preclinical models, which may pave the way for new clinical treatments.
glioblastomadrug conjugatesimmunotherapyEph receptorscytotoxicity
Research Aims
4AIM 01Develop drug conjugates that target multiple receptors in glioblastoma cells.
AIM 02Evaluate the effectiveness of the QUAD-DM1 drug in treating glioblastoma in dogs.
AIM 03Investigate immune responses and tumor characteristics during treatment.
AIM 04Address tumor heterogeneity to improve therapeutic outcomes.
Skills the Lab Values
cell cultureanimal modelingimmunohistochemistrypharmacologymolecular cloningflow cytometrydrug formulationtumor profilingclinical trial design
Output against the department
Publications285top 20% of dept.207th of 1,033
this lab
most publishedleast published
Citations8.5ktop 45% of dept.464th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.