University of South Alabama · PharmacologyLung Response and Mitochondrial Dynamics Lab
Mark N Gillespie · Mobile, Alabama
Research Focus
Dr. Mark Gillespie's lab at the University of South Alabama focuses on understanding how lung cells respond to low oxygen levels and the role of mitochondrial DNA in lung inflammation. The research aims to uncover new mechanisms that regulate gene expression during hypoxia and explore how mitochondrial damage contributes to lung diseases. By studying these processes, the lab seeks to identify potential therapeutic targets for treating conditions like pulmonary hypertension and acute lung injury.
hypoxialung diseasemitochondrial DNAgene regulationinflammationoxidative stressDNA repairpulmonary hypertensionROS
Research Aims
5AIM 01Investigate how hypoxia affects genome-wide RNA expression in lung cells.
AIM 02Explore the role of mitochondrial DNA damage in lung inflammation.
AIM 03Identify the mechanisms by which oxidative stress influences gene regulation.
AIM 04Assess the impact of DNA repair pathways on inflammation resolution.
AIM 05Develop potential drug targets for treating hypoxic lung diseases.
Skills the Lab Values
cell culturemolecular cloningPCRanimal modelsWestern blotRNA sequencingflow cytometrymicroscopyDNA damage repair assaysbioinformatics
Output against the department
Publications214top 40% of dept.183rd of 462
this lab
most publishedleast published
Citations5.1kbottom 38% of dept.287th of 462
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.