WMCWeill Medical College of Cornell University · Biology
Nam MPN Lab
Seung Ha Nam · New York, New York
Research Focus
Dr. Seung Ha Nam's lab at Weill Medical College focuses on studying blood disorders known as myeloproliferative neoplasms (MPNs), particularly how genetic mutations affect responses to treatment. Using advanced techniques like single-cell sequencing, the lab investigates why some patients respond well to interferon therapy while others develop resistance. By understanding these mechanisms, the lab aims to develop more effective therapeutic strategies for treating MPNs.
myeloproliferative neoplasmsinterferon therapygene mutationssingle-cell sequencingtherapy resistance
Research Aims
3AIM 01Investigate the differentiation changes in MPN stem cells after interferon therapy.
AIM 02Identify transcription factor networks involved in therapy resistance.
AIM 03Assess the impact of co-mutations on treatment outcomes in MPN patients.
Skills the Lab Values
single-cell RNA sequencingchromatin accessibility assaysmouse modelsflow cytometrybioinformatics analysis