Transgenerational Epigenetics Lab
Bruce Blumberg · Irvine, California
University of California-Irvine · Biology
Research focus
Dr. Bruce Blumberg's lab at UC Irvine focuses on understanding how prenatal exposure to environmental chemicals, particularly endocrine disruptors, affects obesity in future generations. They study mechanisms of epigenetic inheritance, which could explain how these effects are passed down without changes to DNA. This research aims to uncover how these inherited traits lead to metabolic diseases and how interventions might prevent these transgenerational effects.
epigeneticstransgenerational inheritanceobesityendocrine disruptorschromatin structure
Research aims
3AIM 01Investigate how prenatal TBT exposure alters chromatin structure in germ cells.
AIM 02Identify mechanisms driving gene expression changes in metabolic pathways.
AIM 03Test epigenetic interventions to prevent transgenerational obesity.
Skills the lab values
ChIP-seqgene expression analysisanimal modelsmolecular biology techniquesdata collection and analysis
Output against the department
231publicationstop 27% of the department273rd of 1,033
most publishedleast published
26kcitationstop 15% of the department152nd of 1,033
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. Position on each rail is this lab's rank, not its distance from the top: a department runs from one paper to tens of thousands, so rank is the only comparison that stays readable across it.