University of Chicago · BiologyGajewski Immunotherapy Lab
Thomas F Gajewski · Chicago, Illinois
Research Focus
Dr. Thomas F Gajewski's lab focuses on improving cancer immunotherapy treatments by investigating why some patients do not respond to anti-PD-1 therapies. By studying the immune environment of tumors and the genetics involved, the lab aims to discover new ways to enhance the effectiveness of these therapies. The research combines insights from clinical samples and mouse models to explore various avenues for boosting anti-tumor immune responses.
cancer immunotherapyanti-PD-1T cell responsestumor microenvironmentimmune checkpointsmicrobiota influenceoncogenic eventsimmune resistancegermline variations
Research Aims
5AIM 01Investigate novel T cell immune checkpoints that may enhance immune responses.
AIM 02Explore innate immune strategies to promote new T cell responses in tumors.
AIM 03Identify tumor cell-intrinsic oncogenic events contributing to immune resistance.
AIM 04Examine how the commensal microbiota regulates anti-tumor immunity.
AIM 05Study germline genetic variants that influence anti-tumor T cell responses.
Skills the Lab Values
cell culturemouse modelsflow cytometryimmunohistochemistryRNA sequencinggenomic analysisbiochemical assaysdata analysis in Rmulticolor flow cytometry
Output against the department
Publications635top 4% of dept.40th of 1,033
this lab
most publishedleast published
Citations56ktop 4% of dept.39th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.