Johns Hopkins University · GeneticsFahrner Lab
Jill A Fahrner · Baltimore, Maryland
Research Focus
Dr. Jill A. Fahrner's lab focuses on understanding the genetic and epigenetic factors that lead to growth and neurodevelopmental disorders in children. They study specific conditions known as Weaver and Sotos syndromes, which are characterized by excessive growth and intellectual disabilities. By using a combination of animal models and human cell models, the lab aims to uncover the underlying mechanisms of these diseases and explore new therapeutic options to improve patient outcomes.
epigeneticsneurodevelopmentWeaver syndromeSotos syndromegrowth disordersintellectual disabilitydrug targetingcell modelshuman iPSCchromatin
Research Aims
3AIM 01Establish the neurological phenotype and causal mechanisms in a Weaver syndrome mouse model.
AIM 02Elucidate epigenetic mechanisms of skeletal overgrowth and evaluate treatment in Weaver mice.
AIM 03Determine human disease mechanisms and therapeutic responses in Weaver iPSC models and compare to Sotos.
Skills the Lab Values
mouse modelshuman iPSC culturepharmacological treatment trialsepigenomic profilingtranscriptomic analysisbehavioral assaysCRISPRcell culturegenotypingbiochemical assays
Output against the department
Publications58bottom 11% of dept.229th of 259
this lab
most publishedleast published
Citations2.3kbottom 10% of dept.232nd of 259
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.