University of Kentucky · NeuroscienceCognitive Repair and Cell Therapy Lab
Greg A. Gerhardt · Lexington, Kentucky
Research Focus
Dr. Greg A. Gerhardt's lab at the University of Kentucky focuses on developing new treatments for cognitive decline associated with Alzheimer's disease and related dementias. They conduct clinical trials using cell therapy techniques, specifically delivering nerve tissue to repair neural circuits that are affected in these diseases. The lab's research aims to enhance the function of cholinergic neurons in patients with Alzheimer's and related conditions, potentially offering more than just symptom relief.
Alzheimer's Diseasecell therapydementiacholinergic neuronsclinical trialsneurodegenerative diseasesneural repairperipheral nerve tissuecognitionneuropsychological testing
Research Aims
5AIM 01Investigate the feasibility of cell therapy for Alzheimer's-related cognitive decline.
AIM 02Evaluate the safety of implanting peripheral nerve tissue in brain regions affected by dementia.
AIM 03Assess cognitive function changes over time after treatment in patients.
AIM 04Characterize the histological effects of the treatment using brain bank samples.
AIM 05Enhance understanding of cholinergic neuron function in dementia patients.
Skills the Lab Values
cell cultureclinical trial designneuropsychological testingsurgical proceduresdata collectionpatient recruitmentstatistical analysisdeep brain stimulationtissue implantationexperimental ethics
Output against the department
Publications1,390top 2% of dept.11th of 671
this lab
most publishedleast published
Citations23ktop 17% of dept.117th of 671
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.