Oregon Health & Science University · Microbiology & ImmunologyThe Flagellum Frontier
Scott M Landfear · Portland, Oregon
Research Focus
Dr. Scott M. Landfear's lab at Oregon Health & Science University studies the biology of Leishmania parasites, which cause significant infectious diseases in humans. The lab focuses on understanding the flagellum, a whip-like structure that plays critical roles in the parasite's movement and ability to infect hosts. By investigating how specific proteins traffic to the flagellar membrane and their functions, the research aims to uncover new strategies for controlling these deadly parasites.
Leishmaniaflagellumtraffickingmembrane proteinsparasite biologyinfectionvirulencevector transmission
Research Aims
5AIM 01Investigate how specific flagellar membrane proteins traffic to the flagellar membrane.
AIM 02Determine the biological functions of selected flagellar membrane proteins.
AIM 03Identify other trafficking machines that interact with flagellar membrane proteins.
AIM 04Assess the role of selected flagellar proteins in the life cycle of the parasite.
AIM 05Explore the implications of flagellar membrane function in disease transmission.
Skills the Lab Values
Affinity chromatographyMass spectrometryGene knockout techniquesCell cultureIn vitro assaysImmunofluorescence microscopyProtein purificationBiochemical assaysMolecular cloning
Output against the department
Publications132top 49% of dept.235th of 486
this lab
most publishedleast published
Citations6.8kbottom 49% of dept.250th of 486
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.