University of Pittsburgh-Pittsburgh Campus · Microbiology & ImmunologyShlomchik Immunology Lab
Mark J Shlomchik · Pittsburgh, Pennsylvania
Research Focus
Dr. Mark Shlomchik's lab focuses on understanding how memory B cells develop and function, particularly in response to infections and vaccinations. By studying the molecular and cellular processes in germinal centers, which are key sites for antibody production, the lab aims to uncover how our immune system remembers pathogens and generates long-lasting immunity. This research has implications for vaccine design and understanding various immune-related diseases.
memory B cellsgerminal centervaccine efficacyimmune memorysigaling pathwaystranscription factorsepigeneticspathogen responseautoimmunityantibody production
Research Aims
3AIM 01Investigate the processes that govern memory B cell generation.
AIM 02Determine the molecular and epigenetic circuits controlling distinct memory B cell states.
AIM 03Characterize the surface markers and function of different memory B cell subsets.
Skills the Lab Values
cell culturemouse modelsflow cytometrygenetic engineeringCRISPRRNA sequencingWestern blotimmunohistochemistrytranscription factor analysisdata analysis using Python
Output against the department
Publications431top 7% of dept.36th of 486
this lab
most publishedleast published
Citations34ktop 8% of dept.41st of 486
this lab
most citedleast cited
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