Yale University · Microbiology & ImmunologyType 1 Diabetes Research Laboratory
Kevan C Herold · New Haven, Connecticut
Research Focus
Dr. Kevan C. Herold's lab at Yale University focuses on understanding and developing treatments for Type 1 diabetes, an autoimmune condition where the immune system attacks insulin-producing cells in the pancreas. The lab uses advanced pancreatic organoid models to investigate how different immune responses affect disease progression and treatment outcomes. They aim to uncover important cellular features that could lead to improved therapies and a better understanding of why some patients respond differently to treatments.
Type 1 diabetesautoimmunitypancreatic organoidsimmune therapiesT cell modulation
Research Aims
5AIM 01Develop pancreatic organoid models from patient-derived iPSCs
AIM 02Analyze immune cell interactions with pancreatic organoids
AIM 03Screen for compounds that prevent organoid damage from inflammation
AIM 04Investigate factors influencing patient responses to teplizumab
AIM 05Identify cellular mechanisms leading to operational tolerance in Type 1 diabetes.
Skills the Lab Values
cell cultureinduced pluripotent stem cell (iPSC) technologyflow cytometryRNA sequencingproteomicssingle-cell analysismicroscopydata analysisCRISPR
Output against the department
Publications442top 7% of dept.32nd of 486
this lab
most publishedleast published
Citations33ktop 9% of dept.45th of 486
this lab
most citedleast cited
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