Baylor College of Medicine · BiologyPutluri Lab
Nagireddy Putluri · Houston, Texas
Research Focus
Dr. Nagireddy Putluri's research lab at Baylor College of Medicine focuses on understanding bladder cancer, a disease with significant variation in patient outcomes. The lab investigates how genetic alterations, particularly related to a gene called EPHX2, influence tumor behavior and response to treatments. By analyzing molecular and metabolic changes in tumors, they aim to develop new therapeutic strategies that combine targeting cancer metabolism with immunotherapy to improve patient care.
bladder cancerEPHX2tumor metabolismimmune microenvironmentpersonalized medicinesingle-cell RNA sequencingdrug combination therapymitochondrial dysregulationimmunotherapy
Research Aims
3AIM 01Investigate how EPHX2 deficiency promotes tumor progression in bladder cancer.
AIM 02Determine the mechanisms by which EPHX2 deficiency affects immune cell interactions within tumors.
AIM 03Explore the potential for combining therapies targeting EPHX2 with immune checkpoint inhibitors.
Skills the Lab Values
single-cell RNA sequencingmetabolomic profilingmouse modelsdrug testingimaging mass cytometrypharmacological inhibitioncell culturedata analysistranscriptomics
Output against the department
Publications457top 9% of dept.94th of 1,033
this lab
most publishedleast published
Citations13ktop 28% of dept.291st of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.