University of California-Los Angeles · Microbiology & ImmunologyHoffmann Lab
Alexander Hoffmann · Los Angeles, California
Research Focus
Dr. Alexander Hoffmann's lab at UCLA focuses on understanding how macrophages, which are crucial immune cells, respond to different stimuli and pathogens. The lab studies the mechanisms behind macrophage immune training, which is when past exposures reshape their future responses. By analyzing how these cells undergo epigenomic changes and how different transcription factors like IRFs shape their behavior, the lab aims to uncover insights that could inform treatments for infectious and inflammatory diseases.
macrophagesimmune responseepigenomicstranscription factorssignal transductionimmune traininginflammationsystems biologyCRISPR
Research Aims
3AIM 01Dissect the roles of IRFs in de novo enhancer formation
AIM 02Quantify macrophage stimulus-response specificity
AIM 03Characterize the effects of IRF-mediated chromatin remodeling on gene expression
Skills the Lab Values
ChIP-seqATAC-seqcell culturemolecular cloningCRISPRflow cytometrymouse modelsbioinformaticsdata analysisstatistical modeling
Output against the department
Publications1,528top 1% of dept.1st of 486
this lab
most publishedleast published
Citations79ktop 2% of dept.9th of 486
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.