Louisiana State University Health Sciences Center-Shreveport · Biology

Cardiovascular Macrophage Research Lab

Oren Rom · Shreveport, Louisiana

Research Focus

Dr. Oren Rom's lab focuses on understanding the role of macrophages in cardiovascular diseases, particularly how their metabolism affects plaque stability in atherosclerosis. The research aims to uncover mechanisms behind macrophage behavior, specifically their ability to clear dead cells (efferocytosis) in arterial plaques. By restoring certain metabolic pathways, the lab hopes to find new therapeutic strategies to prevent harmful plaque ruptures and improve cardiovascular health.

macrophagesone-carbon metabolismatherosclerosisplaque stabilityefferocytosiscardiovascular diseasemetabolic pathwaystherapeutic targetsnanoparticlesglycine

Research Aims

AIM 01Define the mechanisms by which macrophage one-carbon metabolism drives efferocytosis.

AIM 02Characterize impaired one-carbon metabolism in human and mouse macrophages during atherosclerosis.

AIM 03Establish the role of one-carbon metabolism in plaque instability and therapy development.

AIM 04Determine the potential of restoring one-carbon metabolism to enhance macrophage function and plaque stability.

Skills the Lab Values

cell culturemouse modelsWestern blotmass spectrometrytranscriptomicspharmacological metabolomicsimaging techniquesPCRbiological assaysdata analysis

Output against the department

Publications111bottom 39% of dept.631st of 1,033

this lab

most publishedleast published

Citations3.5kbottom 26% of dept.763rd of 1,033

this lab

most citedleast cited

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