James Lab
Anthony A. James · Irvine, California
University of California-Irvine · Microbiology & Immunology
Research focus
Dr. Anthony A. James' lab at UC Irvine focuses on developing innovative genetic strategies to combat malaria, a disease that significantly impacts global health. They are particularly interested in using gene-drive systems, which harness CRISPR technology, to alter the reproductive capabilities of malaria-carrying mosquitoes, thereby reducing their populations and spreading resistance to the malaria parasite. The lab's work aims to provide new tools that are effective, safe for humans and the environment, and resilient against reinvasion by susceptible mosquito populations.
malariagene driveCRISPRvector controlmosquitoes
Research aims
3AIM 01Develop gene-drive systems to modify mosquito vector populations for malaria control.
AIM 02Evaluate the impact of these systems on the reproductive success of malaria-carrying mosquitoes.
AIM 03Assess the stability of gene-drive systems across multiple generations of mosquitoes.
Skills the lab values
CRISPR/Cas technologygenetic engineeringDNA analysispopulation biologymolecular genetics
Output against the department
702publicationstop 3% of the department15th of 486
most publishedleast published
34kcitationstop 9% of the department42nd of 486
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. Position on each rail is this lab's rank, not its distance from the top: a department runs from one paper to tens of thousands, so rank is the only comparison that stays readable across it.