University of Maryland-College Park · Engineering · Biomedical EngineeringLab for Immune Tolerance Research
Christopher M Jewell · College Park, Maryland
Research Focus
Dr. Christopher M Jewell's lab focuses on developing innovative approaches to treat autoimmune diseases like multiple sclerosis and type 1 diabetes by promoting immune tolerance. The lab employs techniques such as microneedle arrays to deliver therapeutic antigens and regulate immune responses, aiming to create therapies that are both effective and have fewer side effects than current treatments. Students in the lab will engage in cutting-edge research that combines engineering with immunology to explore how immune system modulation can combat autoimmune disorders.
autoimmunityimmune tolerancemicroneedle arraysmultiple sclerosisantigen-specific therapeutic strategiesregulatory T cellsbiomaterialslocal lymph node depots
Research Aims
3AIM 01Investigate how microneedle arrays can influence innate immune signaling in the skin.
AIM 02Define the structural and functional changes in lymph nodes associated with T cell tolerance.
AIM 03Assess the long-term effectiveness of the microneedle technology in pre-clinical autoimmune models.
Skills the Lab Values
3D printingflow cytometrycell cultureanimal modelingconfocal microscopyimmunotherapy techniquesbiomaterial fabricationantigen presentationregulatory T cell analysis
Output against the department
Publications214top 48% of dept.410th of 868
this lab
most publishedleast published
Citations8.9ktop 39% of dept.341st of 868
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.