Tulane University of Louisiana · PhysiologyZhuo Hypertension Lab
Jia Long Zhuo · New Orleans, Louisiana
Research Focus
Dr. Jia Long Zhuo’s lab at Tulane University studies the mechanisms behind high blood pressure and kidney injury, focusing on a specific mitochondrial protein called Sirtuin 3. Their research aims to understand the role of Sirtuin 3 in regulating blood pressure and protecting the kidneys from damage caused by conditions like hypertension. By working with unique mouse models, the lab hopes to uncover how targeting Sirtuin 3 could lead to new treatments for hypertension and related kidney issues.
HypertensionKidney InjuryMitochondrial DysfunctionSirtuin 3Angiotensin IIIschemiaReactive Oxygen SpeciesSex DimorphismDrug Development
Research Aims
3AIM 01Investigate the role of Sirtuin 3 in Ang II-induced hypertension in mouse models.
AIM 02Examine how Sirtuin 3 affects kidney injury during ischemia and reperfusion.
AIM 03Elucidate the molecular mechanisms by which Sirtuin 3 influences mitochondrial function.
Skills the Lab Values
Mouse modelsMitochondrial assaysMolecular cloningCRISPR/Cas technologyBiochemical analysisCell culture techniquesWestern blottingFlow cytometryExperimental designSignal pathway analysis
Output against the department
Publications217top 29% of dept.83rd of 286
this lab
most publishedleast published
Citations5.4kbottom 45% of dept.157th of 286
this lab
most citedleast cited
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