Vanderbilt University · BiologyEichman Lab
Brandt F Eichman · Nashville, Tennessee
Research Focus
Dr. Brandt F. Eichman’s lab at Vanderbilt University focuses on understanding how our cells replicate DNA and repair any damage that might occur during this process. Their research is crucial because mistakes in DNA replication can lead to cancer and other diseases. The team investigates the complex interactions between various proteins involved in DNA replication, aiming to uncover how these proteins work together to maintain genomic stability and prevent disease.
DNA replicationgenomic stabilityDNA repairprotein interactionscancer research
Research Aims
5AIM 01Investigate the molecular mechanisms of DNA replication.
AIM 02Elucidate how proteins involved in DNA repair interact with DNA.
AIM 03Characterize the enzymatic activities of DNA glycosylases and translocases.
AIM 04Determine the structural dynamics of multiprotein-DNA complexes at replication forks.
AIM 05Understand how defects in DNA repair pathways contribute to cancer.
Skills the Lab Values
DNA purificationprotein expression and purificationelectron microscopybiochemical assayscell cultureDNA sequencingmolecular cloningsite-directed mutagenesisbioinformaticsimmunoprecipitation
Output against the department
Publications162top 41% of dept.422nd of 1,033
this lab
most publishedleast published
Citations4.3kbottom 32% of dept.697th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.