Yale University · NeuroscienceSestan Neurobiology Lab
Nenad Sestan · New Haven, Connecticut
Research Focus
Dr. Nenad Sestan's lab at Yale University focuses on understanding how the brain's cellular diversity affects aging and Alzheimer's disease. They study how specific cells in the hippocampal and entorhinal regions of the brain respond to Alzheimer's pathology and explore the molecular mechanisms behind this process. By employing advanced sequencing techniques, the lab aims to uncover patterns that may lead to better insights and treatments for Alzheimer's disease.
Alzheimer's diseasecell diversityhippocampusentorhinal cortexagingsingle-cell RNA sequencingchromatin accessibilitygene regulationneurobiology
Research Aims
5AIM 01Investigate the molecular diversity of neuronal and non-neuronal cells in the hippocampal-entorhinal cortex of Alzheimer’s disease brains.
AIM 02Compare gene expression and regulatory patterns between healthy and Alzheimer’s affected brains.
AIM 03Identify biomarkers for early detection of Alzheimer’s disease through advanced sequencing techniques.
AIM 04Explore the resilience mechanisms of specific cell types in the brain during aging.
AIM 05Develop a comprehensive cell census of the hippocampal-entorhinal system in humans and rhesus macaques.
Skills the Lab Values
single nuclear RNA sequencing (snRNA-seq)single nuclear ATAC sequencing (snATAC-seq)cell culturemolecular profiling techniquesdata analysis using genomics toolshistological methodsRNA extractionchromatin assaysbioinformatics analysis
Output against the department
Publications271top 26% of dept.175th of 671
this lab
most publishedleast published
Citations42ktop 8% of dept.53rd of 671
this lab
most citedleast cited
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