Yale University · BiologyNeuronal Lysosome Research Lab
Shawn Ferguson · New Haven, Connecticut
Research Focus
The Ferguson lab at Yale University focuses on understanding how lysosomes function in neurons, particularly in the context of Alzheimer's disease. They investigate the proteins JIP3 and JIP4, which play crucial roles in regulating lysosome movement and signaling within nerve cells. By uncovering the mechanisms that affect lysosome behavior, the lab aims to contribute to the development of therapeutic strategies for neurodegenerative diseases.
lysosomesAlzheimer's diseaseJIP3JIP4neuron signalingprotein regulationneurodegenerative diseasescellular distributionvesicle buddingiPSCs
Research Aims
3AIM 01Define pathways regulating JIP3 and JIP4 in lysosome distribution.
AIM 02Investigate how JIP3 and JIP4 influence vesicle budding in lysosomes.
AIM 03Assess the physiological impacts of JIP3 and JIP4 on neuronal lysosomes.
Skills the Lab Values
cell culturegenetically modified miceRNA sequencingWestern blotimmunofluorescenceinduced pluripotent stem cell (iPSC) techniquesneuron differentiationmicroscopybiochemical assayssignal transduction analysis
Output against the department
Publications147top 46% of dept.478th of 1,033
this lab
most publishedleast published
Citations11ktop 35% of dept.358th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.