University of Texas Southwestern Medical Center · PharmacologyZhang Lab
Xuewu Zhang · Dallas, Texas
Research Focus
Dr. Xuewu Zhang's lab at UT Southwestern Medical Center focuses on studying the STING protein, which is crucial for the body's defense against viruses and cancer. The lab works to uncover how STING is regulated and aims to develop new drugs that activate STING to enhance immune responses. This research could lead to innovative treatments for cancer and viral infections.
STINGinnate immunitycGAScGAMPcancer therapyviral infectionsimmune response
Research Aims
5AIM 01Investigate the regulatory mechanisms of the STING protein using cryo-EM
AIM 02Characterize a novel binding site for STING agonists
AIM 03Design and synthesize new STING agonists for research purposes
AIM 04Test the efficacy of new agonists in functional assays
AIM 05Explore the potential of STING agonists in cancer therapy.
Skills the Lab Values
cryogenic electron microscopy (cryo-EM)biophysical assayscell culturemolecular cloningdrug designprotein purificationimmunoblottingchemical synthesis
Output against the department
Publications201top 44% of dept.201st of 462
this lab
most publishedleast published
Citations7.0ktop 50% of dept.233rd of 462
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.