University of Minnesota-Twin Cities · PharmacologyNeurotensin Receptor Research Lab
Lauren M Slosky · Minneapolis, Minnesota
Research Focus
Dr. Lauren M Slosky's lab focuses on finding new ways to treat opioid use disorder by investigating a brain receptor called neurotensin receptor 1 (NTSR1). They aim to develop small molecules that can help prevent relapse in individuals recovering from opioid addiction. The research explores how these molecules work in the brain, potentially leading to safer and more effective treatments for opioid dependency.
opioid use disorderneurotensin receptor 1drug discoverysmall molecule probesaddiction treatment
Research Aims
5AIM 01Validate NTSR1 as a drug target for opioid use disorder.
AIM 02Discover new small molecules that selectively target NTSR1.
AIM 03Characterize the signaling mechanisms of NTSR1 in relation to opioid effects.
AIM 04Test the efficacy of new compounds in mouse models of opioid relapse.
AIM 05Develop therapeutic strategies to reduce relapse rates in opioid addiction.
Skills the Lab Values
cell culturemouse modelspharmacology techniquesbiochemical assaysmedicinal chemistrydrug efficacy testingsignaling pathway analysiscompound synthesisbehavioral neuroscience
Output against the department
Publications39bottom 4% of dept.444th of 462
this lab
most publishedleast published
Citations1.3kbottom 6% of dept.432nd of 462
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.