University of North Carolina at Chapel Hill · ChemistryRedinbo Lab
Matthew R Redinbo · Chapel Hill, North Carolina
Research Focus
Dr. Matthew R. Redinbo's lab at the University of North Carolina Chapel Hill focuses on understanding how gut microbial enzymes affect human health and disease. Their research explores the roles of these enzymes in various conditions, including infections and chronic diseases like kidney and heart disease, by investigating their structures and functions. The lab employs advanced techniques to discover new ways to target these microbial proteins, with the goal of developing innovative diagnostics and therapeutics.
gut microbiomebile salt hydrolasesindole metabolismenzyme inhibitorsgut healthhuman diseasemulti-omicsmicrobial proteinsClostridioides difficileantepartum depression
Research Aims
5AIM 01Examine the structures and functions of gut microbial enzymes.
AIM 02Identify the role of bile salt hydrolases in Clostridioides difficile infection.
AIM 03Characterize tryptophan-indole lyases and their role in kidney and heart diseases.
AIM 04Explore the impact of -glucuronidases on neurotransmitter levels in pregnant women.
AIM 05Develop novel inhibitors to target gut microbial enzymes associated with disease.
Skills the Lab Values
structural biologybiochemistryanimal modelsenzyme kineticsprotein characterizationchemical biology techniquesmulti-omics approacheshuman clinical samples analysisbacterial culturedrug design
Output against the department
Publications368top 30% of dept.65th of 216
this lab
most publishedleast published
Citations18ktop 26% of dept.57th of 216
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.