University of California-Merced · EngineeringDe Alba Bastarrechea Inflammasome Lab
Eva De Alba Bastarrechea · Merced, California
Research Focus
Dr. Eva De Alba Bastarrechea's lab at UC Merced focuses on understanding how inflammasomes, which are complexes in immune cells, regulate inflammation in response to infections or tissue damage. By studying the molecular dynamics of proteins involved in these complexes, her research aims to uncover new targets for anti-inflammatory therapies. The lab employs advanced techniques to visualize and manipulate these proteins, contributing to the development of drugs for various inflammatory diseases, including cancer and autoimmune disorders.
inflammasomespattern recognition receptorsDNA bindinganti-inflammatory therapyautoimmune diseasesbiophysical analysisprotein dynamicsdrug designsingle-molecule techniquescytokine signaling
Research Aims
5AIM 01Investigate the regulatory mechanisms of inflammasome assembly.
AIM 02Characterize the biophysical dynamics of pattern recognition receptors.
AIM 03Develop peptides that can inhibit inflammasome activity.
AIM 04Explore the relationship between DNA binding and receptor oligomerization.
AIM 05Design therapeutic strategies targeting aberrant inflammation.
Skills the Lab Values
NMR spectroscopysingle-molecule microscopybiochemical assaysoptical trappingcell cultureprotein purificationfluorescence microscopydata modelingpeptide design
Output against the department
Publications1bottom 1% of dept.274th of 278
this lab
most publishedleast published
Citations0bottom 1% of dept.275th of 278
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.