University of Illinois Chicago · PharmacologyThe ThromboSignal Lab
Xiaoping Du · Chicago, Illinois
Research Focus
Dr. Xiaoping Du's lab at the University of Illinois At Chicago focuses on understanding how specific proteins called integrins signal cells to trigger blood clotting and inflammation. The research aims to develop new medications that can prevent harmful blood clots without causing serious bleeding, addressing a critical need in treating conditions like heart attacks and strokes. By investigating these mechanisms, the lab seeks to create safer dual-action therapies for thrombotic and inflammatory diseases.
integrin signalinganti-plateletanti-inflammatorythrombosiscoagulationsepsiscardiovascular diseasesdrug developmentthrombo-inflammation
Research Aims
5AIM 01Investigate the mechanisms of Ga13-dependent integrin outside-in signaling.
AIM 02Develop dual anti-platelet and anti-coagulant drugs with minimal bleeding risk.
AIM 03Explore the role of integrin signaling in leukocyte functions during inflammation.
AIM 04Create new treatments for severe sepsis by targeting thrombo-inflammatory pathways.
AIM 05Understand the impact of platelet and leukocyte interactions on thrombosis and inflammation.
Skills the Lab Values
cell cultureWestern blotflow cytometrymouse modelsPCRanimal modelingbiochemical assaysdrug formulationsignal transduction analysis
Output against the department
Publications276top 28% of dept.130th of 462
this lab
most publishedleast published
Citations9.4ktop 41% of dept.188th of 462
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.