University of Florida · Microbiology & ImmunologyPancreatic Islet Autoimmunity Lab
Clayton E Mathews · Gainesville, Florida
Research Focus
Dr. Clayton Mathews' lab focuses on understanding how autoimmune processes trigger Type 1 diabetes (T1D) by studying the pancreatic islet cells. They investigate specific proteins that may change in structure due to various chemical modifications, potentially serving as signals for the immune system to attack. By characterizing these changes in affected individuals, the lab aims to discover new biomarkers and insights that could help prevent T1D in at-risk people.
Type 1 diabetesautoimmunityneoantigenshyperglycemiaproteomics
Research Aims
3AIM 01Discover in situ posttranslational modifications in pancreatic islets
AIM 02Validate potential neoepitopes through proteomic techniques
AIM 03Characterize T-cell reactivity to identified neoepitopes
Skills the Lab Values
mass spectrometryprotein characterizationflow cytometrybioinformaticscell culture
Output against the department
Publications264top 21% of dept.101st of 486
this lab
most publishedleast published
Citations8.2ktop 44% of dept.214th of 486
this lab
most citedleast cited
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