Stanford University · NeuroscienceNeuroGlioma Nexus
Michelle Monje-Deisseroth · Stanford, California
Research Focus
Dr. Michelle Monje-Deisseroth's lab at Stanford University focuses on understanding how neurons contribute to the growth and formation of low-grade gliomas, a common type of brain tumor, particularly in children with Neurofibromatosis type 1 (NF1). Their research aims to explore the interactions between nerve cells and tumor cells to enhance treatment options and reduce long-term side effects in young patients. The lab employs various techniques to study the biological mechanisms behind these tumors and how they can be targeted for better therapies.
gliomaneurofibromatosis type 1neuronal signalingbrain tumor biologytumor microenvironment
Research Aims
5AIM 01Investigate the role of neuronal activity in the initiation of low-grade gliomas.
AIM 02Elucidate the molecular mechanisms by which neuroligin-3 influences glioma growth.
AIM 03Analyze how Nf1 mutations affect neuronal signaling in tumor development.
AIM 04Explore potential therapeutic targets to reduce tumor growth in NF1-OPG.
AIM 05Determine the interactions between neuronal and tumor cells in the glioma microenvironment.
Skills the Lab Values
mouse modelscell culturein vivo imagingmolecular biology techniquesgenetic manipulationimmunohistochemistrybiochemical assaysdata analysis using Python